FD2056 - CAS 2685870-87-3

FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. Additionally, it exhibits inhibitory effects on CDK2-CyclinA2 and CDK4-CyclinD3 with IC50s of 115.95 nM and 2782.15 nM. FD2056 effectively inhibits the proliferation of various breast cancer cell lines, such as MDA-MB-231, MDA-MB-468, and MCF-7, with IC50s of 1.06 μM, 0.04 μM, and 1.40 μM, respectively. The compound also promotes apoptosis in cancerous cells and has been shown to suppress tumor growth [1].

PI3K

PI3K/Akt/mTOR signaling

2685780

C23H17ClN6O2S

476.94

NC1=CC(C=2C=3C(NC2)=NC=C(C3)C=4C=C(NS(=O)(=O)C5=CC=CC=C5)C(Cl)=NC4)=CC=N1

-20°C

Ice Packs

Small Compound