Ferroptosis inducer-8 - CAS 3097194-74-3

Ferroptosisinducer-8 is a ferroptosis (iron-dependent cell death) inducer with high selectivity against other cell death pathways. It induces ferroptosis by affecting ACSL4, GPX4, and FTH1, disrupting intracellular iron homeostasis and the GSH/GPX4 antioxidant defense system, leading to the accumulation of lipid peroxides. Ferroptosisinducer-8 also stimulates ROS production and can inhibit tumor growth, making it useful for research in triple-negative breast cancer (TNBC) .

Glutathione Peroxidase, ROS, Ferroptosis

Metabolism, Immunology/Inflammation, Apoptosis

3097117

C22H25Cl2NO7

486.34

C(N(C(CCl)=O)C1=CC(OC)=C(Cl)C(OC)=C1)C=2[C@@]3([C@@](C(C(OC)=O)=CO[C@H]3OC)(CC2)[H])[H]

-20°C

Ice Packs

Small Compound