FFA2 agonist-1 - CAS 1312799-06-6

FFA2 agonist-1 (Compound 4) is an agonist of the free fatty acid receptor 2 (FFA2/GPR43) with an EC50 of 81 nM. It demonstrates activity in β-arrestin-2 recruitment and cAMP inhibition assays, with EC50 values of 1.2 μM and 0.53 μM, respectively. FFA2 agonist-1 can induce the mucosal response of appetite-regulating peptide YY (PYY), inhibit fat accumulation, and affect intestinal function and food intake, making it useful for obesity research.

GPCR

GPCR/G Protein, Endocrinology/Hormones

1312799-06-6

C25H22ClNO4

435.899

C(=O)(N1[C@H](CC[C@H]1C(O)=O)C2=C(Cl)C=CC=C2)C3=CC=C(C=C3)C4=C(OC)C=CC=C4

-20°C

Ice Packs

Small Compound