FGFR-IN-13 - CAS 2962941-25-7

FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 ± 0.02 nM) and FGFR4 (IC 50 = 0.40 ± 0.03 nM) . It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].

FGFR

Tyrosine Kinase/Adaptors, Angiogenesis

2962941-25-7

C23H21N5O3

415.44

C(N1C=2C(=C(N=CN2)C3=CC(OC)=CC(OC)=C3)N=C1)C4=CC=C(NC(C=C)=O)C=C4

-20°C

Ice Packs

Small Compound