FGFR-IN-8 - CAS 2640217-64-5

FGFR-IN-8 is a potent, orally active FGFR inhibitor that inhibits both wild-type and mutant FGFR. FGFR-IN-8 acts on FGFR1 (IC50<0.5 nM), V564F-FGFR2 (IC5016: 189.1 nM), N549H-FGFR2 (IC50<0.5 nM), V555M-FGFR3 (IC50: 22.6 nM), FGFR3 (IC50<0.5 nM) and FGFR 4 (IC50: 7.30 nM), V555M-FGFR3 (IC50: 22.6 nM), FGFR3 (IC50<0.5 nM) and FGFR 4 (IC50: 7.30 nM) . FGFR-IN-8 induces apoptosis and exhibits anti-cancer effects.

Apoptosis, FGFR, Others

Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, Others

2640148

C27H31Cl2N9O2

584.5

N(C1=C(C=CC=N1)C=2N=C(NC3=CN(N=C3)C4CCN(C(C)C)CC4)N=CN2)C5=C(Cl)C(OC)=CC(OC)=C5Cl

-20°C

Ice Packs

Small Compound