FGTI-2734 mesylate (1247018-19-4 free base) - CAS 2702297-24-1

FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.

Ras, Others, Kras, Transferase

Metabolism, MAPK, Others

2702272

C27H35FN6O5S2

606.73

OS(=O)(C)=O.O=S(C1=NC=CC=C1)(N(CCN(C2=CC=C(C#N)C=C2F)CC3=CN=CN3C)CC4CCCCC4)=O

-20°C

Ice Packs

Small Compound