FHND5032 - CAS 3076057-63-8

FHND5032 is an orally active miR-124 inducer that significantly enhances miR-124 expression in macrophages. It inhibits the PIK3R2/PI3K/Akt axis to block inflammatory signaling, facilitates macrophage reprogramming, and restores epithelial barrier function. FHND5032 alleviates colitis and reduces inflammatory burden in ulcerative colitis mouse models, making it useful for ulcerative colitis research.

Interleukin, PI3K, Akt, Antibacterial

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Immunology/Inflammation, Microbiology/Virology

3075986

C15H9ClF3N3O

339.7

FC(F)(F)OC1=CC=C(C=C1)NC=2N=CC3=CC=C(Cl)C=C3N2

-20°C

Ice Packs

Small Compound