FKBP12 ligand-3 - CAS 3036374-26-9

FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. It is utilized to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching drugs intracellularly through the "CellTrap" effect to form an FKBP12-ligand-BRD4 ternary complex. This complex inhibits BRD4, reducing the expression of BRD4 target genes such as MYC, leading to tumor cell death. FKBP12 ligand-3 can be applied in selective cancer research based on differences in intracellular presenter protein levels.

FKBP

Apoptosis, Immunology/Inflammation, Autophagy

3036339

C25H27Cl2N3O4S

536.47

S(=O)(=O)(N1[C@]2([C@@H](COCC#C)CN([C@@H](C)C3=CC=CC=N3)C(=O)[C@@]1(CCC2)[H])[H])C4=CC(Cl)=CC(Cl)=C4

-20°C

Ice Packs

Small Compound