FKK6 - CAS 2238839-34-2

FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 of 1.2 μM. It demonstrates strong affinity for plasma proteins and exhibits favorable metabolic characteristics in human microsomes. FKK6 inhibits the PXR-related NF-κB signaling pathway, reducing the expression of inflammatory factors and showing anti-inflammatory activity in a mouse model of DSS-induced colitis.

Interleukin, NF-κB

NF-κB, Immunology/Inflammation

2238803

C23H18N2O3S

402.47

O=S(=O)(C=1C=CC=CC1)N2C=3C=CC=CC3C=C2C(O)(C=4C=CN=CC4)CC#C

-20°C

Ice Packs

Small Compound