FL442 - CAS 1431166-12-9

FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL) .

Androgen Receptor

Endocrinology/Hormones

1431145

C15H13F3N2O

294.27

N#CC=1C=CC(=CC1C(F)(F)F)C2=NOC3CCCCC23

-20°C

Ice Packs

Small Compound