Flavokawain B - CAS 1775-97-9

1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.

ROS, PI3K, Bcl-2 Family, Caspase, NF-κB, Akt, p38 MAPK, PARP, Apoptosis, MMP

Chromatin/Epigenetic, Cytoskeletal Signaling, NF-κB, MAPK, DNA Damage/DNA Repair, Immunology/Inflammation, PI3K/Akt/mTOR signaling, Apoptosis, Proteases/Proteasome

1669

>99.99%

C17H16O4

284.31

COC1=CC(OC)=C(C(=O)\C=C\C2=CC=CC=C2)C(O)=C1

-20°C

Ice Packs

Natural Product