Flavopiridol - CAS 146426-40-6

Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Phase 1/2.

Autophagy, HIV Protease, Apoptosis, CDK

Cell Cycle/Checkpoint, Autophagy, Proteases/Proteasome, Apoptosis, Microbiology/Virology

146380

0.9999

C21H20ClNO5

401.84

CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl

-20°C

Ice Packs

Small Compound