FLT3-IN-12 - CAS 2499966-67-3

FLT3-IN-12 is a selective, potent, orally active FLT3 kinase inhibitor that acts on FLT3-WT (IC50: 1.48 nM) and FLT3-D835Y (IC50: 2.87 nM) . FLT3-IN-12 is more selective than c-KIT (>1000-fold) . FLT3-IN-12 showed significant anti-AML effects, with an IC50 value of 0.75 nM for MV4-11 cells.

Others, FLT

Others, Tyrosine Kinase/Adaptors, Angiogenesis

2499896

C21H23F3N6O

432.44

O=C1C=2C(=CC(NC=3N=C(N[C@@H]4CC[C@H](N)CC4)C(C(F)(F)F)=CN3)=CC2)C=CN1C

-20°C

Ice Packs

Small Compound