FLT3-IN-31 - CAS 2290545-53-6

FLT3-IN-31 (compound 10q) is a potent FLT3 inhibitor, with IC50 values of 0.16 nM for FLT3 and 2.4 nM for FLT3-D835Y, exhibiting antiproliferative activity. It reduces protein expression of p-FLT3, P-STAT5, and P-ERK. Additionally, FLT3-IN-31 induces apoptosis and causes cell cycle arrest at the G1 phase, displaying antitumor properties.

FLT, Apoptosis

Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors

2290486

C25H24FN5O

429.49

C(=C/C1=CC(F)=C(CN2CCOCC2)C=C1)\C=3C=4C(=CC(=CC4)C=5C=C(N)N=CC5)NN3

-20°C

Ice Packs

Small Compound