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FLT3/ITD-IN-3 - CAS 2489446-47-9

FLT3/ITD-IN-3 - CAS 2489446-47-9

MF-0140734-01

$1,383.80 USD
$1,383.80 USD
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Product Details

  • Bioactivity

    FLT3/ITD-IN-3 (Compound 19) is a potent inhibitor of FLT3-ITD, demonstrating efficacy against FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM), and FLT3-ITD (IC50: 0.9 nM) . It significantly inhibits FLT3 phosphorylation and effectively suppresses the proliferation of AML cells.

  • Target

    Others, FLT

  • Related Pathways

    Tyrosine Kinase/Adaptors, Others, Angiogenesis

  • CAS Number

    2489390

  • Molecular Formula

    C22H26ClN7O2

  • Molecular Weight

    455.94

  • SMILES

    C(NC1=C(Cl)C=C(C=C1)N2CCOCC2)(=O)C3=C4N(N=C3)C=CC(N[C@@H]5CCCNC5)=N4

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound