FLT3-ITD-IN-3 - CAS 3018150-80-3

FLT3-ITD-IN-3 (13v) is an orally active inhibitor of FLT3-ITD (internal tandem duplication of FLT3), which works by blocking FLT3 signaling. This inhibition leads to cell cycle arrest in the G0/G1 phase and induces apoptosis. The compound is currently employed in studies related to acute myeloid leukemia (AML) .

Apoptosis, FLT

Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis

3018067

C27H21ClF2N6O5

582.943

O=C1C=C(C(=NN1C2=CC(Cl)=CC=C2F)C(=O)NC3=CC=C(OC=4C=CN=C(C4)NC(=O)N5CC(O)C5)C(F)=C3)C

-20°C

Ice Packs

Small Compound