Flucopride - CAS 1639925-34-0

Flucopride (Compound 4a) acts as an acetylcholinesterase inhibitor (AChE) with an IC50 value of 24 nM and serves as a partial agonist for the human 5-HT4 receptor (5-HT4R) with a Ki of 9.6 nM for (h) 5-HT4R. It promotes non-amyloidogenic processing of APP in COS-7 cells transiently expressing (h) 5-HT4R with an EC50 of 23.0 nM. Flucopride is also likely to exhibit significant gastrointestinal tract (GIT) penetration and blood-brain barrier (BBB) permeability, as determined in PAMPA experiments.

Cholinesterase (ChE), 5-HT Receptor

GPCR/G Protein, Neuroscience

1639891

C22H33FN2O2

376.51

O=C(C1=CC(F)=C(N)C=C1OC)CCC2CCN(CC2)CC3CCCCC3

-20°C

Ice Packs

Small Compound