Fludarabine Phosphate - CAS 75607-67-9

Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

DNA/RNA Synthesis, Apoptosis, Nucleoside Antimetabolite/Analog

Apoptosis, Cell Cycle/Checkpoint, DNA Damage/DNA Repair

75531

>99.99%

C10H13FN5O7P

365.21

Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O

-20°C

Ice Packs

Small Compound