Fluphenazine hydrochloride - CAS 1254-47-3

Fluphenazine hydrochloride is an effective, orally active phenothiazine class dopamine receptor (dopamine receptor) antagonist. It blocks voltage-gated sodium ion channels (sodium channels) in neurons. The compound primarily exerts its effects by antagonizing postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular pathways. It counteracts stereotypy induced by methylphenidate in mice and suppresses climbing behavior. Fluphenazine hydrochloride is used in studying psychoses and diabetic-related painful peripheral neuropathy, with potential to inhibit SARS-CoV-2.

Sodium Channel, SARS-CoV, Dopamine Receptor

Microbiology/Virology, GPCR/G Protein, Neuroscience, Membrane transporter/Ion channel

1204

C22H27ClF3N3OS

473.98

Cl.FC(F)(F)C1=CC=C2SC=3C=CC=CC3N(C2=C1)CCCN4CCN(CCO)CC4

-20°C

Ice Packs

Small Compound