Molfinity

FM-381 - CAS 2226521-65-7

SKU:MF-0018775-01

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Product Details

Bioactivity
FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Target
JAK
Related Pathways
Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling, Stem Cells
CAS Number
2226449
Purity
0.9933
Molecular Formula
C24H24N6O2
Molecular Weight
428.49
SMILES
CN(C)C(=O)C(=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1)\C#N
Storage Temperature
-20°C
Shipping Conditions
Ice Packs
Category
Small Compound