FMF-04-159-2 - CAS 2364489-81-4

FMF-04-159-2 is a potent covalent cell cycle protein-dependent kinase 14 (CDK14) inhibitor with IC50 of 39.6 nM for CDK14 and 256 nM for CDK2.FMF-04-159-2 is able to reduce α-synuclein (α-Syn) aggregation in neurons and plays a role in Parkinson's disease models, and also inhibits triple-negative breast cancer (TNBC) progression and metastasis by attenuating Wnt/β-catenin signaling.

Others, CDK, Wnt/beta-catenin

Cell Cycle/Checkpoint, Stem Cells, Others, Cytoskeletal Signaling

2364404

0.9657

C28H30Cl3N7O5S

683.01

N(C(=O)C1=C(Cl)C=C(Cl)C=C1Cl)C=2C(C(NC3CCN(S(=O)(=O)C4=CC(NC(/C=C/CN(C)C)=O)=CC=C4)CC3)=O)=NNC2

-20°C

Ice Packs

Small Compound