FO-4-15 - CAS 1030759-58-0

FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.

GluR, CaMK, Microtubule Associated

Neuroscience, Cytoskeletal Signaling

1030701

C18H20N4O4S

388.44

O=S(=O)(C1=CC=C(C=C1)C)N2CCN(CC3=NC(=NO3)C=4OC=CC4)CC2

-20°C

Ice Packs

Small Compound