FOG-001 - CAS 3044032-95-0

FOG-001 is an efficient inhibitor of β-catenin, with an IC50 value lower than 50 nM. This compound can block the interaction between β-catenin and T-cell factor (TCF) transcription factors, thereby interfering with the related signaling pathways. FOG-001 can effectively inhibit cell proliferation and induce cell cycle arrest. In a mouse xenograft tumor model carrying COLO320DM colon cancer cells (with APC and TP53 mutations), FOG-001 exhibits significant anti-tumor activity. Therefore, FOG-001 is applicable to the research on the mechanism of colon cancer occurrence and treatment.

Wnt/beta-catenin

Cytoskeletal Signaling, Stem Cells

3044032-95-0

C102H134N18O25S2

2076.39

-20°C

Ice Packs

Peptide