Forodesine hydrochloride - CAS 284490-13-7

Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.

Apoptosis, Nucleoside Antimetabolite/Analog, Others

Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair, Apoptosis

284470

C11H15ClN4O4

302.71

Cl.OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1[nH]cnc2=O

-20°C

Ice Packs

Small Compound