FR900098 (sodium salt) - CAS 73226-73-0

FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively) . FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.

Parasite, Others, Antibiotic

Others, Microbiology/Virology

73153

C5H12NNaO5P

220.117

[Na].CC(=O)N(O)CCCP(O)(O)=O

-20°C

Ice Packs

Small Compound