FTI 277 TFA - CAS 1217447-06-7

FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM) . Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.

Others, Apoptosis, Ras, Transferase

MAPK, Apoptosis, Metabolism, Others

1217447-06-7

C24H30F3N3O5S2

561.64

OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1

-20°C

Ice Packs

Small Compound