FTR-1335 - CAS 851075-79-1

FTR1335 is a CaNMT inhibitor (IC50 = 0.49 nM) with good fungal selectivity. CaNMT inhibitors are fungicidal and show antifungal activity against Candida (especially fluconazole-resistant strains) . They function by inhibiting N-myristoyltransferase (NMT), which catalyzes the transfer of a C14 fatty acif from myristoyl-CoA to the N-terminal of glycine in many fungal proteins. Without this process, fungi can die. This process also occurs in humans, and as such selectivity is an important characteristic of these drugs.

Others

Others

850995

C31H34N4O2S

526.69

N(C(=O)C1CCCC1)C=2SC=3C(N2)=CC=C(NC(=O)[C@H]4C[C@@H](NCC5=CC6=C(C=C5)C=CC=C6)CCC4)C3

-20°C

Ice Packs

Small Compound