Fumaric acid - CAS 110-17-8

Fumaric acid (2-Butenedioic acid) attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.

Endogenous Metabolite, NF-κB, p38 MAPK

NF-κB, MAPK, Metabolism

85

0.9928

C4H4O4

116.07

C(=C/C(O)=O)\C(O)=O

-20°C

Ice Packs

Natural Product