Funalenone - CAS 259728-61-5

Funalenone is a phenalenone originally isolated from A. niger. It inhibits HIV-1 integrase (IC50 = 10 μM) and HIV-1 replication in human peripheral blood cells transformed by murine leukemia virus (HPB-M (a) ; IC50 = 1.7 μM) but is less cytotoxic to mammalian HPB-M (a) cells (IC50 = 87 μM) . Funalenone selectively inhibits matrix metalloproteinase-1 (MMP-1; IC50 = 170 μM) over MMP-2 and MMP-9, which it inhibits by 18.3 and 38.2%, respectively, when used at a concentration of 400 μM. It also inhibits the bacterial cell wall synthesis enzymes MraY and MurG (IC50s = 25.5 μM in a membrane plate assay) and inhibits growth of S. aureus with a MIC value of 64 μg/mL.

Antibacterial, Others, HIV Protease, MMP

Microbiology/Virology, Others, Proteases/Proteasome

259662

C15H12O6

288.255

COC1=C(O)c2c(O)cc(C)c3c(O)cc(O)c(C1=O)c23 |c:2|

-20°C

Ice Packs

Small Compound