Fusaproliferin - CAS 152469-17-5

Fusaproliferin is a diterpene mycotoxin identified in Fusarium solani. Fusaproliferin can reverse Lipopolysaccharides stimulation and the NF-κB and MAPKs signaling pathways, thus playing a role in anti-inflammatory processes. It has affinity for the TLR4 protein with a KD value of 28.6 μM. Fusaproliferin exhibits cytotoxicity against pancreatic cancer, showing rapid submicromolar IC50 effects.

Interleukin, IκB/IKK, NF-κB, p38 MAPK, Reactive Oxygen Species, ERK, TNF, NO Synthase

Immunology/Inflammation, MAPK, Metabolism, Apoptosis, NF-κB

152469-17-5

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