FXIIa-IN-5 - CAS 3047411-80-0

FXIIa-IN-5 (Compound 4J) is an orally effective selective inhibitor of factor XIIa (FXIIa), with an IC50 of 21 nM. It inhibits the intrinsic coagulation pathway and demonstrates anti-inflammatory and antithrombotic activities in a Carrageenan-induced thrombosis model in mice. FXIIa-IN-5 exhibits moderate pharmacokinetic properties and mild toxicity at a dosage of 100 mg/kg.

Thrombin

Proteases/Proteasome

3047331

C26H29N7O

455.55

O=C(C1=CC=C(C=2C=CC=CC12)N3CCN(CCC3)C(C)C)N4N=C(N=C4N)C=5N=CC=CC5

-20°C

Ice Packs

Small Compound