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Molfinity

FzM1 - CAS 1680196-54-6

FzM1 - CAS 1680196-54-6

MF-0012846-01

$36.16 USD
$36.16 USD
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Product Details

  • Bioactivity

    FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.

  • Target

    Wnt/beta-catenin

  • Related Pathways

    Stem Cells, Cytoskeletal Signaling

  • CAS Number

    1680136

  • Purity

    0.9989

  • Molecular Formula

    C21H16N2O2S

  • Molecular Weight

    360.43

  • SMILES

    Oc1cc(NC(=O)Nc2ccc3ccccc3c2)cc(c1)-c1cccs1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound