G-631 - CAS 1507370-78-6

G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.

PARP

DNA Damage/DNA Repair, Chromatin/Epigenetic

1507286

C19H22F2N6O3

420.41

O=C1N=C(NC2=C1C=NN2C)N3CCN(C4=C(F)C=C(OCCOC)C=C4F)CC3

-20°C

Ice Packs

Small Compound