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Molfinity

G12Si-5 - CAS 2946593-46-8

G12Si-5 - CAS 2946593-46-8

MF-0049826-01

$3,388.89 USD
$3,388.89 USD
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Product Details

  • Bioactivity

    G12Si-5 is a covalent inhibitor of the K-RasG12S mutant with a Ki value of 26 μM. It binds to the S-IIP structural domain, inhibiting oncogenic signaling and reducing ERK phosphorylation levels in KRAS G12S mutant cells.

  • Target

    Others, Kras, Ras

  • Related Pathways

    MAPK, Others

  • CAS Number

    2946539

  • Molecular Formula

    C31H29ClFN5O3

  • Molecular Weight

    574.05

  • SMILES

    C(OC=1N=C(C2=C(N1)C(F)=C(N=C2)C=3C4=C(C=CC3)C=CC=C4Cl)N5C[C@]6([C@@](CC5)(C(=O)O6)[H])[H])C78N(CCC7)CCC8

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound