GA-017 - CAS 2351906-74-4

GA-017 is a potent, selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2), exhibiting IC50 values of 4.10 and 3.92 nM, respectively. This compound simultaneously acts as an activator of cell proliferation by promoting YAP/TAZ activation and their nuclear translocation. Additionally, GA-017 enhances cell growth in 3D culture conditions and augments the ex vivo formation of mouse intestinal organoids [1].

Others, YAP

Stem Cells, Others

2351828

0.9938

C18H21N3O4

343.38

CC\C(=N\NC(=O)NCc1cccc(O)c1)c1ccc(O)c(C)c1O

-20°C

Ice Packs

Small Compound