GABAA receptor agent 5 - CAS 1808389-92-5

GABAA receptor agent 5 demonstrates antagonist activity across multiple GABAA receptor subtypes, and GABAA receptor agent 5 exhibits IC50 values of 0.24, 0.088, 0.068, 0.33, 0.79, 0.32, 0.079, and 0.051 μM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, and α5β2γ2 receptor configurations, respectively. GABAA receptor agent 5 (compound 018) thereby provides a precise pharmacological tool for characterizing subtype-selective GABAA receptor inhibition and supports mechanistic neuropharmacology studies focused on inhibitory synaptic signaling and therapeutic antagonist development.

GABA Receptor

Membrane transporter/Ion channel, Neuroscience

1808292

0.9939

C21H25N3O2S

383.51

O=C(NC1=CC=CC(=C1)C(=O)N2CCC3(CCNCC3)CC2)C=4SC=CC4

-20°C

Ice Packs

Small Compound