Gamma-secretase modulator 6 - CAS 1255700-88-9

Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.

Gamma-secretase, Beta Amyloid

Proteases/Proteasome, Stem Cells, Neuroscience

1255603

C25H26N6O2

442.513

O(C)C1=C(C=CC(NC=2N=C3C(=CC2)CN(C)C[C@H](O3)C4=CC=CC=C4)=N1)C5=CN(C)N=C5

-20°C

Ice Packs

Small Compound