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GCN2 activator-1 - CAS 315705-10-3

GCN2 activator-1 - CAS 315705-10-3

MF-0118870-01

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Product Details

  • Bioactivity

    GCN2 activator-1 (Compound 20) is a GCN2 activator that binds to the ATP pocket of GCN2 and activates it in a GCN1-independent manner. It can stimulate the integrated stress response (ISR) in cells and inhibits PKR with an IC50 of 3.75 μM. GCN2 activator-1 is utilized for research on pulmonary veno-occlusive disease (PVOD) .

  • Target

    PERK

  • Related Pathways

    Apoptosis

  • CAS Number

    315692

  • Molecular Formula

    C11H10N6S2

  • Molecular Weight

    290.37

  • SMILES

    N=1C=CC=NC1NC2=NC(=CS2)C=3SC(=NC3C)N

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound