GDC-0134 - CAS 1637394-01-4

GDC-0134, a dual leucine zipper kinase (DLK) inhibitor, exhibits brain penetration properties. It inhibits DLK to prevent neuronal degeneration and block JNK activation, potentially treating amyotrophic lateral sclerosis (ALS) . It has been assessed in a phase 1 study aimed at treating ALS patients.

JNK

MAPK

1637394-01-4

C19H20F4N6O2

440.4

FC1(F)CN(C=2N=C(C=C(N2)C=3C=C(OC(F)F)C(N)=NC3)N4[C@]5(C[C@@](C4)(OC5)[H])[H])CC1

-20°C

Ice Packs

Small Compound