GDC-2394 - CAS 2238822-07-4

GDC-2394, an orally active, selective NLRP3 inhibitor, also targets IL-1β, exhibiting inhibitory concentrations (IC50s) of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β) . It effectively hampers NLRP3-induced caspase-1 activity while not affecting NLRC4-dependent inflammasome activation.

Others, Caspase, NOD-like Receptor (NLR), Interleukin

Immunology/Inflammation, Others, Apoptosis, Proteases/Proteasome

2238822-07-4

C20H25N5O4S

431.51

N(C(NS(=O)(=O)C1=C2N(N=C1)C[C@H](NC)CO2)=O)C3=C4C(=CC5=C3CCC5)CCC4

-20°C

Ice Packs

Small Compound