GDC-2992 - CAS 2753651-10-2

GDC-2992 is a selective and orally active androgen receptor (AR) degradator that degrades AR (DC50 = 2.7 nM) and inhibits proliferation (IC50 = 9.7 nM) in VCaP cells, making it suitable for studying castration-resistant prostate cancer (CRPC) .

Androgen Receptor, PROTACs

Endocrinology/Hormones, PROTAC

2753639

0.9982

C45H51ClN8O5

819.39

O([C@H]1C(C)(C)[C@H](NC(=O)C2=CC=C(C=C2)N3CCC(CN4CCN(CC4)C=5C=C6C(=CC5)C(=O)N(N=C6)[C@@H]7C(=O)NC(=O)CC7)CC3)C1(C)C)C8=CC(Cl)=C(C#N)C=C8

-20°C

Ice Packs

PROTAC