GDCNF-11 - CAS 2991588-80-6

GDCNF-11, an HSP90-based HIM-PROTACGPX4 degrader, facilitates the ubiquitination and degradation of GPX4 through the HSP90 chaperone complex. This reduction in endogenous GPX4 induces ferroptosis in HT-1080 cells, with a DC50 value of 0.08 μM.

PROTACs, Ferroptosis, Glutathione Peroxidase

Apoptosis, Metabolism, PROTAC

2991502

C48H53Cl2N13O5S

994.99

O=C(NCCC=1C=CC=CC1)C(C=2SC=CC2)N(C(=O)CCl)C3=CC=C(OCC=4N=NN(C4)CC(=O)N5CCC(CCNC6=NC(=NC7=C6N=CN7CC8=NC=C(C(OC)=C8C)C)N)CC5)C(Cl)=C3

-20°C

Ice Packs

PROTAC