GE1111 - CAS 2883669-12-1

GE1111 is an antagonist of the mas-related G protein-coupled receptor X2 (MRGPRX2), exhibiting an IC50 of 9.42 μM. It inhibits mast cell degranulation with an IC50 of 4.7 μM. In the C48/80-induced systemic allergic reaction model, GE1111 demonstrates both antiallergic and anti-inflammatory properties.

MRGPR

GPCR/G Protein

2883656

C28H22N2O5

466.485

O=CC1=CC=2C=C(C=C3C=CC(O)=C(C32)C1C)C4=CC=5C=CC(=CC5C=C4C(=O)OC)NC(=O)N

-20°C

Ice Packs

Small Compound