GED-0507-34 Levo - CAS 921195-93-9

GED-0507-34 Levo ((S) -3- (4-Aminophenyl) -2-methoxypropanoic acid), an orally available PPARγ modulator for amelioration of inflammation-driven intestinal fibrosis, decreased the expression of the pro-fibrotic genes Acta2, COL1a1, and Fn1, reduced the protein levels of α-SMA and collagen I-II, the main markers of fibrosis, as well as the major components of the TGFβ/Smad pathway, and decreased the expression of IL-13, CTGF, TGFB and ACTA1, and inhibited TGF-β-induced activation of fibroblasts and IECs cell lines.

Interleukin, PPAR, TGF-beta/Smad

Stem Cells, Immunology/Inflammation, DNA Damage/DNA Repair, Metabolism

921093

0.9819

C10H13NO3

195.22

C([C@@H](C(O)=O)OC)C1=CC=C(N)C=C1

-20°C

Ice Packs

Small Compound