Gefitinib-based PROTAC 3 - CAS 2230821-27-7

Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].

EGFR, PROTACs

JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors, PROTAC

2230821-27-7

0.9825

C47H57ClFN7O8S

934.51

N(C=1C2=C(C=C(OC)C(OCCCCCOCCOCCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=C2)N=CN1)C6=CC(Cl)=C(F)C=C6

-20°C

Ice Packs

PROTAC