Gefitinib dihydrochloride - CAS 184475-56-7

Gefitinib dihydrochloride is a potent, selective, orally active EGFR tyrosine kinase inhibitor (IC50: 33 nM) . Gefitinib dihydrochloride selectively inhibits EGF-stimulated tumor cell growth with an IC50 value of 54 nM and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Gefitinib dihydrochloride induces autophagy and apoptosis, and can be used in studies of cancer-related diseases such as lung and breast cancer.

Others, Apoptosis, EGFR, Autophagy

Apoptosis, Angiogenesis, Autophagy, Tyrosine Kinase/Adaptors, Others, JAK/STAT signaling

184412

C22H26Cl3FN4O3

519.82

Cl.Cl.COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1

-20°C

Ice Packs

Small Compound