Gefitinib impurity 1 - CAS 675126-26-8

Gefitinib impurity 1 is a compound derived from Gefitinib, a potent and selective EGFR tyrosine kinase inhibitor (IC 50 = 33 nM) . This orally active compound selectively inhibits tumor cell growth stimulated by EGF (IC 50 = 54 nM) and inhibits EGFR autophosphorylation induced by EGF in tumor cells. Additionally, Gefitinib induces autophagy and exhibits antitumor activity.

Others, Drug Metabolite

Metabolism, Others

675092

C15H19N3O5

321.33

COc1cc(c(cc1OCCCN1CCOCC1)C#N)[N+]([O-])=O

-20°C

Ice Packs

Small Compound