Gemfibrozil-d6 - CAS 1184986-45-5

Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.

PPAR, Cytochromes P450

Metabolism, DNA Damage/DNA Repair

1184936

C15H16D6O3

256.37

O(CCCC(C(O)=O)(C([2H])([2H])[2H])C([2H])([2H])[2H])C1=C(C)C=CC(C)=C1

-20°C

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