Gepotidacin hydrochloride - CAS 1075235-46-9

Gepotidacin hydrochloride, also known as GSK-2140944 hydrochloride, is a potent Type II DNA topoisomerase inhibitor. Gepotidacin hydrochloride is a novel antibacterial drug candidate. Gepotidacin hydrochloride Demonstrates Absence of Fluoroquinolone-Like Arthropathy in Juvenile Rats. Gepotidacin hydrochloride is efficacious in a nonhuman primate model of pneumonic plague. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, Gepotidacin hydrochloride inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively.

Others, Antibacterial, Topoisomerase, Antibiotic

DNA Damage/DNA Repair, Microbiology/Virology, Others

1075180

C24H29ClN6O3

484.98

C([C@H]1N2C=3N(C1)C(=O)C=CC3N=CC2=O)N4CCC(NCC=5C=C6C(=CN5)OCCC6)CC4.Cl

-20°C

Ice Packs

Small Compound