GI-Y2 - CAS 1008710-58-4

GI-Y2 is a GSDMD inhibitor that suppresses macrophage pyroptosis induced by oxidized low-density lipoprotein (ox-LDL) . In vivo, GI-Y2 dose-dependently reduces atherosclerotic plaques and decreases lesion size and fibrosis in the aortic root of ApoE-/- mice. GI-Y2 holds potential for research in pyroptosis and cardiovascular diseases, such as atherosclerosis.

Pyroptosis

Apoptosis, Immunology/Inflammation

1008648

C18H14N2O6S

386.379

O=C(O)C1=CC=C(C=C1)NC2SC(=O)N(C2=O)CC3=CC=C(C=C3)C(=O)O

-20°C

Ice Packs

Small Compound